According to a research report published by Spherical Insights & Consulting, the Global Small Interfering RNA (siRNA) Therapeutics Market Size Expected to Grow from USD 1.8 Billion in 2023 to USD 6.89 Billion by 2033, at a CAGR of 14.37% during the forecast period 2023-2033.

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Targeting harmful genes with tiny synthetic RNA molecules is known as small interfering RNA (siRNA) treatment. The market for siRNA therapeutics is expanding due to the growing need for precision drug delivery, innovative delivery techniques, and improved molecular understanding of the chemicals that cause disease. Additionally, the rising incidence of chronic disorders presents exciting opportunities for developing and distributing medications based entirely on short-interfering RNA. Additionally, the market for small interfering RNA (siRNA) treatment regimens is currently expanding due to increased financing and advancements in technology. The market for small interfering RNA (siRNA) treatments is growing globally as a result of improved RNA delivery techniques, growing financing for RNA-based drug discovery, and growing demand for targeted medications. With siRNA therapeutics, certain genes can be silenced, enabling more targeted treatment of rare and inherited illnesses. The market is growing due to expanding applications in cardiovascular disease, cancer, and viral infections, as well as regulatory support and fruitful clinical trials. However, maintaining stability while avoiding immunological reactions is a challenge for efficient delivery strategies. Market expansion is further hampered by high development costs, regulatory restrictions, and a lack of awareness about RNA-based medications, particularly in countries with less developed healthcare systems.

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Browse key industry insights spread across 245 pages with 110 Market data tables and figures & charts from the report on the Global Small Interfering RNA (siRNA) Therapeutics Market Size, Share, and COVID-19 Impact Analysis, By Delivery (Lipid Nanoparticles (LNPs), Conjugates), By Indication (Hereditary Transthyretin-mediated Amyloidosis, Acute Hepatic Porphyria, Primary Hyperoxaluria Type 1, Primary Hypercholesterolemia, Others), By RoA (Intravenous (IV), Subcutaneous), and By Region (North America, Europe, Asia Pacific, Latin America, Middle East, and Africa), Analysis and Forecast 2023 – 2033

The lipid nanoparticles (LNPs) segment is expected to hold the largest share of the global small interfering RNA (siRNA) therapeutics market during the forecast period.

Based on delivery, the global small interfering RNA (siRNA) therapeutics market is categorized as lipid nanoparticles (LNPs), and conjugates. Among these, the lipid nanoparticles (LNPs) segment is expected to hold the largest share of the global small interfering RNA (siRNA) therapeutics market during the forecast period. Their exceptional ability to boost siRNA stability, protect against degradation, and enhance targeted dispersion is what is responsible for their growth. Because LNPs ensure precise gene silencing through efficient encapsulation, their use in therapeutic applications is growing.

The primary hyperoxaluria type 1 segment is expected to grow at the fastest CAGR during the forecast period.        

Based on the indication, the global small interfering RNA (siRNA) therapeutics market is categorized as hereditary transthyretin-mediated amyloidosis, acute hepatic porphyria, primary hyperoxaluria type 1, primary hypercholesterolemia, and others. Among these, the primary hyperoxaluria type 1 segment is expected to grow at the fastest CAGR during the forecast period. This is a result of both heightened awareness of the illness and the recent approval of lumasiran, a PH1-specific siRNA therapy. Significant market expansion in this field is also driven by the growing emphasis on treating uncommon genetic illnesses, as well as by expanded clinical studies and creative therapy developments.

The subcutaneous segment is expected to hold the largest share of the global small interfering RNA (siRNA) therapeutics market during the forecast period.

Based on RoA, the global small interfering RNA (siRNA) therapeutics market is categorized as intravenous (IV) or subcutaneous. Among these, the subcutaneous segment is expected to hold the largest share of the global small interfering RNA (siRNA) therapeutics market during the forecast period. This is because self-administration is easy, patients are more compliant, and fewer doctor visits are required. In addition to increasing patient accessibility, the subcutaneous distribution has been widely utilized in siRNA therapy for conditions like primary hyperoxaluria type 1 and hereditary transthyretin-mediated amyloidosis, which has contributed to its market dominance.

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North America is anticipated to hold the largest share of the global small interfering RNA (siRNA) therapeutics market over the forecast period.

North America is projected to hold the largest share of the global small interfering RNA (siRNA) therapeutics market over the forecast period. A strong healthcare infrastructure and significant expenditures in biotechnology and pharmaceuticals are the main drivers of this expansion. Significant academic and scientific institutions in the area foster innovation and siRNA treatments in clinical studies. Additionally, the need for tailored treatment and growing awareness of genetic disorders increase market potential in North America, solidifying its position as the industry leader.

Europe is expected to grow at the fastest CAGR growth of the global small interfering RNA (siRNA) therapeutics market during the forecast period. The region benefits from a robust regulatory environment that encourages the discovery of novel therapeutics and also an increasing emphasis on customized medicine. Market growth is also being driven by higher expenditures in research & development, along with the rising prevalence of genetic disorders.

Competitive Analysis:

The report offers the appropriate analysis of the key organizations/companies involved within the global small interfering RNA (siRNA) therapeutics market along with a comparative evaluation primarily based on their product offering, business overviews, geographic presence, enterprise strategies, segment market share, and SWOT analysis. The report also provides an elaborative analysis focusing on the current news and developments of the companies, which includes product development, innovations, joint ventures, partnerships, mergers & acquisitions, strategic alliances, and others. This allows for the evaluation of the overall competition within the market. Major vendors in the global small interfering RNA (siRNA) therapeutics market are Alnylam, Quark Pharmaceuticals, Dicerna Pharmaceuticals, Arrowhead Pharmaceuticals, Novartis, Novo Nordisk, Johnson & Johnson Company, GSK, Silence Therapeutics, Silenseed Ltd, Sylentis, S.A., Sanofi Genzyme, Aro Biotherapeutics, and others.

Key Target Audience

• Market Players
• Investors
• End-users
• Government Authorities
• Consulting and Research Firm
• Venture capitalists
• Value-Added Resellers (VARs)

Key Market Development

• In May 2024,Wave Life Sciences revealed continuous success in their collaboration with GSK, including significant advances in siRNA and RNA editing. Wave collaborated with GSK to identify its first two initiatives for future development after successfully verifying their targets. These applications made use of Wave’s sophisticated GalNAc-siRNA format, which represents the next generation of hepatology technology.
• In May 2024, A clinical trial led by Mount Sinai researchers found that small interfering RNA (siRNA) investigational therapy that inhibits a gene involved in lipoprotein metabolism significantly reduced levels of different types of cholesterol and triglycerides in people with mixed hyperlipidemia, a condition in which fats accumulate in the blood.

Market Segment

This study forecasts revenue at global, regional, and country levels from 2020 to 2033. Spherical Insights has segmented the global small interfering RNA (siRNA) therapeutics market based on the below-mentioned segments:

Global Small Interfering RNA (siRNA) Therapeutics Market, By Delivery

• Lipid Nanoparticles (LNPs)
• Conjugates

Global Small Interfering RNA (siRNA) Therapeutics Market, By Indication

• Hereditary Transthyretin-mediated Amyloidosis
• Acute Hepatic Porphyria
• Primary Hyperoxaluria Type 1
• Primary Hypercholesterolemia
• Others

Global Small Interfering RNA (siRNA) Therapeutics Market, RoA

• Intravenous (IV)
• Subcutaneous

Global Small Interfering RNA (siRNA) Therapeutics Market, By Regional

• North America

• • US
  • Canada
  • Mexico

• Europe

• • Germany
  • UK
  • France
  • Italy
  • Spain
  • Russia
  • Rest of Europe

• Asia Pacific

• • China
  • Japan
  • India
  • South Korea
  • Australia
  • Rest of Asia Pacific

• South America

• • Brazil
  • Argentina
  • Rest of South America

• Middle East & Africa

• • UAE
  • Saudi Arabia
  • Qatar
  • South Africa
  • Rest of the Middle East & Africa

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